2027
Bacteriophage Biology $ Genomics Lab / Islamic University Bangladesh
Decoding Phage Biology. Advancing Phage-Based Solutions to Antimicrobial Resistance.
Phage Research in Bangladesh: From AMR Challenges to Precision Antimicrobial Solutions.
Publications
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Lab members
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Phages banked
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Phage-Bbgl
About Us
The Bacteriophage Biology and Genomics Lab (BBGL) is part of the Department of Biotechnology and Genetic Engineering at Islamic University Bangladesh. The lab is jointly led by Dr. Sudhangshu Kumar Biswas, Professor, whose research focuses on bioremediation, drug-resistant bacteria, and bacteriophage biology, including phage therapy against multidrug-resistant pathogens like Shigella, and Dr. Hossain Md. Faruquee, Ph.D. (ICGEB-Arturo Falaschi Fellow), Professor, whose research spans biotechnology, molecular biology, pharmacogenomics, and metabolomics, including disease biomarker discovery in conditions like Alzheimer’s and Parkinson’s.
Together, our research combines molecular biology, genomics, and applied microbiology to develop alternative strategies against drug-resistant infections and to address environmental contamination through bacterial bioremediation.
Our work spans:
- Bacteriophage isolation, characterization, and therapeutic applications
- Drug-resistant bacteria and antimicrobial resistance mechanisms
- Genomics, pharmacogenomics, and disease biomarker discovery
- Bioremediation using bacterial and plant-derived agents
ENDOLYSIN · AMIDASE_3 · LysM
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Purifying selection across most endolysin sites · diversifying selection at host-adaptation loci. Specific cell-wall binding domains track distinct streptococcal hosts.
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01. Research focus
Our Research
Five interconnected programs spanning isolation to translation.
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Lytic phages · MDR hosts · In vivo
Phage Therapy
Isolation, characterization and therapeutic evaluation of lytic phages against clinically relevant MDR pathogens, with in vivo efficacy studies.
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Receptors · Evolution · Escape
Phage–Host Interactions
In silico and experimental modeling of phage–bacteria dynamics: receptor specificity, evolutionary patterns, resistance escape.
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Gut & skin phageomes · Endolysins
Microbiome Science
Gut and skin phageome mining — uncovering modular endolysins and microbial community roles in health and disease.
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WGS · ANI phylogeny · Taxonomy
Phage Genomics & Bioinformatics
Comparative genomics, taxonomy, ANI phylogeny and proteome clustering across hundreds of phage genomes.
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Endolysins · AMPs · Delivery
Phage-Derived Antimicrobials
Engineered phages, endolysins, depolymerases and endolysin-derived AMPs as targeted clinical antimicrobials.
SUST · SYLHET
Bangladesh · One Health resource
One Health phage bank for Bangladesh
Environmentally stable, biofilm-active, genomically safe isolates for human, animal and environmental use.
02 · How we work
From Discovery to Therapeutic Potential
A rigorous six-stage workflow applied to every candidate phage.
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STAGE 01
Isolation
Hospital sewage, clinical, farm & municipal sources.
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STAGE 02
Characterization
MOI, one-step growth, pH & thermal stability.
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STAGE 03
Genomic Analysis
WGS, virulence & AMR-gene exclusion, taxonomy.
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STAGE 04
Host Interaction
Receptor mapping, biofilm models, escape dynamics.
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STAGE 05
Therapeutic Evaluation
Biofilm disruption, delivery (e.g. hydrogel), in vivo.
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STAGE 06
Translation
Banking, One Health deployment, clinical pathways.
03 · Ongoing projects
Featured Research
Phage Bank · One Health
Developing a phage bank in Bangladesh: a rapid, cost-effective tool against AMR
Lytic phages targeting K. pneumoniae, E. coli, S. aureus, Enterobacter and more — stable across temperature and pH, active against antibiotic-tolerant biofilms, genomically safe.
Comparative Genomics
Streptococcus phage genomes: diversity, taxonomy and novel endolysin-derived AMPs
709 genomes · 66 clusters · 21 proposed families · 296 genus subclusters · 182 novel endolysin-derived antimicrobial peptides with MD-validated binding.
Phage Bank · One Health
Developing a phage bank in Bangladesh: a rapid, cost-effective tool against AMR
Lytic phages targeting K. pneumoniae, E. coli, S. aureus, Enterobacter and more — stable across temperature and pH, active against antibiotic-tolerant biofilms, genomically safe.
Comparative Genomics
Streptococcus phage genomes: diversity, taxonomy and novel endolysin-derived AMPs
709 genomes · 66 clusters · 21 proposed families · 296 genus subclusters · 182 novel endolysin-derived antimicrobial peptides with MD-validated binding.
04 · Lab at a glance — verified counts
Peer-reviewed publications
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Lab members & alumni
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Bacterial strains banked
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Lytic phages banked
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Counts verified from the lab’s publication list, member roster, and microbial database.
06 · The laboratory
A dynamic, progressive scientific environment.
Led by Prof. Md Shakhinur Islam Mondal and Prof. Mst Arzuba Akter, our team spans principal investigators, co-investigators, PhD and MS researchers, and accomplished alumni now at CHRF, icddr,b and UCF.
In vivo and in silico. Wet-lab isolation plus comparative genomics, modeling and molecular dynamics.
Clinical, molecular, translational. From sewage and swabs to biofilms, hydrogels and banks.
Open resources. Publications, phage–host bank and methods shared with the community.
Md Shakhinur Islam Mondal, PhD
Professor & Principal Investigator
Genetic Engineering & Biotechnology, SUST
Mst Arzuba Akter, PhD
Professor
Biochemistry & Molecular Biology, SUST
G. M. Nurnabi Azad Jewel
Assistant Professor & Co-investigator
Genetic Engineering & Biotechnology, SUST
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Students & Alumni
PhD · MS · Alumni network
CHRF · icddr,b · UCF · NSTU
07 · In the lab & field
Gallery
Microscopy & characterization
Microscopy & characterization
Microscopy & characterization
Microscopy & characterization
Microscopy & characterization
08 · Why phage research
A precise answer to imprecise antibiotics.
Bacteriophages kill bacteria with extraordinary specificity — without the collateral damage of broad-spectrum antibiotics. Our program follows this logic end to end.
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Antibiotic Resistance
MDR pathogens outpacing new antibiotics, especially in LMICs.
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Targeted Killing
Lytic phages lyse only their host — sparing the microbiome.
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Phage Discovery
Environmentally sourced, locally produced isolates.
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Genomic Characterization
Safety-screened, taxonomy-resolved, banked.
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Therapeutic Research
Biofilms, delivery systems, in vivo evaluation.
Building the next generation of precision antimicrobials.
Explore our research, publications, people, and microbial resources.
